Registration Dossier
Registration Dossier
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EC number: 876-151-9 | CAS number: 2292123-68-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No specific toxicological studies have been performed on this substance. A review of the available test data do not permit extensive conclusions concerning absorption, metabolism or excretion to be drawn. No effects were observed in the available studies.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Repeated oral administration of the test substance in three OECD studies:
- 90-day sub-chronic study to rats (OECD 408)
- 28 day sub-acute study to rats (OECD 407)
- Reproductive screening test (OECD 421)
All three studies provided NOAEL values of 1000 mg/kg/day.
No mortality was observed in available acute oral or inhalation toxicity studies.
Overall, no treatment related effects were observed in the sub-chronic repeated dose toxicity study which indicates that the substance is not easily absorbed by the human body. These findings were supported by other studies where no treatment related changes were observed in any of the developmental or reproductive parameters in the OECD 421 study, possibly indicating low adsorption through the placenta to directly affect the foetuses and similarly as no effects were observed in pups during the lactation phase, low exposure to the developing pups via lactation is likely.
Although a positive response was observed in an in vitro chromosome aberration assay, this effect was not replicated in vivo.
The substance also has a low BCF value from the available aquatic bioaccumulation study, and accordingly there is no bioaccumulation potential for the substance.
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