Ethyl [2-(4-phenoxyphenoxy)ethyl]carbamate

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 Jan 2000 to 21 Jan 2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

other: CIPAC method MT 157.3 (water solubility: flask method)

GLP compliance:

yes

Medium:

acetone

Solubility:

> 500 g/L

Temp.:

25 °C

Medium:

other: dichloromethane

Solubility:

> 500 g/L

Temp.:

25 °C

Medium:

ethyl acetate

Solubility:

> 500 g/L

Temp.:

25 °C

Key result

Medium:

other: hexane

Solubility:

4.6 g/L

Temp.:

25 °C

Medium:

methanol

Solubility:

> 500 g/L

Temp.:

25 °C

Medium:

n-octanol

Solubility:

110 g/L

Temp.:

25 °C

Medium:

toluene

Solubility:

> 500 g/L

Temp.:

25 °C

Test substance stable:

yes

RESULTS

Table 1 Experimental data

Acetone	Amount of test substance (g) dissolved in solvent to a final volume less than 10.0 mL Solubility (g/L)	5.86   > 500
Dichloromethane	Amount of test substance (g) dissolved in solvent to a final volume less than 10.0 mL Solubility (g/L)	5.37   >500
Ethyl acetate	Amount of test substance (g) dissolved in solvent to a final volume less than 10.0 mL Solubility (g/L)	5.49   >500
Hexane	Amount of test substance (g) dispersed in 50 mL of solvent Equilibration time at 25°C Solubility (g/L) Average (g/L)	2.86   1 day      2 days 4.484     4.649 4.6
Methanol	Amount of test substance (g) dissolved in solvent to a final volume less than 10.0 mL Solubility (g/L)	5.26   >500
Octanol	Amount of test substance (g) dispersed in 75 mL of solvent Equilibration time at 25°C Solubility (g/L) Average (g/L)	18.09   1 day      2 days 108.657    110.961 110
Toluene	Amount of test substance (g) dispersed in 50.0 mL of solvent Solubility (g/L)	5.37   >500

The results for the average of the solubilities have been quoted correct to two significant figures, where appropriate.

Conclusions:

The solubility in seven different organic solvents has been determined ranged from 4.6 g/L in hexane to >500 g/L in acetone, dichloromethane, ethyl acetate, methanol and toluene.

Executive summary:

The solubility of test substance has been determined in seven organic solvents. As there is no general method available for the determination of the solubility in organic solvents, a procedure similar to that described in CIPAC method MT 157.3 (water solubility: flask method) was used in this study in compliance with GLP. The solubility was found to range from 4.6 g/L in hexane to >500 g/L in acetone, dichloromethane, ethyl acetate, methanol and toluene.

Description of key information

The solubility in seven organic solvents ranged from 4.6 g/L in hexane to >500 g/L in acetone, dichloromethane, ethyl acetate, methanol and toluene, CIPAC MT 157.3, Kettner 2000

Key value for chemical safety assessment

At the temperature of:

25 °C

Solubility in organic solvents at 20°C:

4.6 g/L