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Physical & Chemical properties

Melting point / freezing point

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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes
Type of method:
thermal analysis

Test material

Constituent 1
Chemical structure
Reference substance name:
2-({(5S)-2-Oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
EC Number:
610-201-0
Cas Number:
446292-08-6
Molecular formula:
C22 H19 N3 O6
IUPAC Name:
2-({(5S)-2-Oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Results and discussion

Melting / freezing pointopen allclose all
Key result
Melting / freezing pt.:
216.53 °C
Remarks on result:
other: pressure not reported; (closed crucible, after recrystallization), mean value out of three measurements
Key result
Melting / freezing pt.:
219.6 °C
Remarks on result:
other: pressure not reported; (open crucible, after recrystallization), mean value out of three measurements

Any other information on results incl. tables

Mean value of these six determinations: 218.1°C, pressure not reported.

Applicant's summary and conclusion

Conclusions:
The sample is closed up in a crucible made of aluminium and heated up in a DTA-system (heat­ ing rate 1 K/min). In comparison with an inert sample the temperature difference and the heat effect is recorded. The melting curve of the sample is a steep endothermic signal.
Executive summary:

Oxaphthalimid has a melting point of 216.47°C, 216.62°C, 216.52°C (closed crucible, after recrystallization) and of 219.45°C, 219.54°C, 219.80°C (open crucible, after recrystallization). Mean value of these six determinations = 218.1°C. The pressure is not reported.