Registration Dossier
Registration Dossier
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EC number: 840-202-3 | CAS number: 2101947-22-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 17 July 2017. Experimental completion date: 08 August 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study is considered to be a reliability 1 as it has been conducted according to OECD TG 117 (n-octanol/water) and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Identification: FRET 15-0735
Appearance/physical state: clear, colorless liquid
Storage conditions: approximately 4 °C, in the dark - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 3.15
- Temp.:
- 30 °C
- pH:
- 7.2
- Details on results:
- Mean Log 10 Pow: 3.15
Partition coefficient: 1.40 x 10^3
pH:7.2 - Conclusions:
- The partition coefficient of FRET 15-0735 has been determined as log P 3.15 at 30°C under OECD TG 117 (n-octanol/water) in compliance with GLP.
- Executive summary:
The partition coefficient of FRET 15-0735 has been determined as log P 3.15 at 30°C under OECD TG 117 (n-octanol/water).
Reference
Discussion
In the absence of any relevant dissociating functional groups, no specific manipulation of the mobile phase pH was required to ensure that the test item was analyzed in a non-ionized form. Therefore the determination was performed at an unadjusted, approximately neutral pH.
Description of key information
The partition coefficient of FRET 15-0735 has been determined experimentally as log P 3.15 at 30°C under OECD TG 117 (n-octanol/water).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.15
- at the temperature of:
- 30 °C
Additional information
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