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EC number: 840-202-3 | CAS number: 2101947-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 10 May 2018 and 11 June 2018.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliability 1 is assigned because the study conducted according to OECD TG (2006) No 111 in compliance with GLP, without deviations that influence the quality of the results.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identification: FRET 15-0735
Appearance/physical state: clear, colorless liquid
Storage conditions: room temperature, in the dark - Analytical monitoring:
- yes
- Remarks:
- High performance liquid chromatography (HPLC)
- Details on sampling:
- The sample solutions were taken from the waterbath at various times and the pH of each solution recorded.
Samples
Duplicate aliquots (A and B) of each initial sample solution were diluted by a factor of 4, using methanol, for analysis. For the following samples, duplicate, independently incubated vessels were removed from the waterbath for each pH under evaluation, at each time point. An aliquot of each incubated sample was then diluted by a factor of 4, using methanol, prior to analysis.
Standards
Duplicate standard solutions of test item were prepared in methanol: relevant buffer solution (75:25 v/v) at a nominal concentration of 100 mg/L.
Matrix blanks
Methanol: relevant buffer solution (75:25 v/v). - Buffers:
- The test system consisted of sterile buffer solutions at pH’s 4, 7 and 9.
Buffer solution(pH) Components Concentration(mol dm-3)
4 Citric acid 0.06
Sodium chloride 0.04
Sodium hydroxide 0.07
7 Disodium hydrogen orthophosphate (anhydrous) 0.03
Potassium dihydrogen orthophosphate 0.02
Sodium chloride 0.02
9 Disodium tetraborate 0.01
Sodium chloride 0.02
These solutions were subjected to ultrasonication and degassing with nitrogen to minimize dissolved oxygen content. - Details on test conditions:
- Preparation of the Test Solutions
Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 0.40 g/L in the three buffer solutions. A 1% co-solvent of acetonitrile was used to aid solubility.
The test solutions were split into individual vessels for each data point.
The solutions were shielded from light whilst maintained at the test temperature.
Preliminary Test
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of 120 hours. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.4 g/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.4 g/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.39 g/L
- Number of replicates:
- Duplicate
- Positive controls:
- no
- Negative controls:
- yes
- Remarks:
- Matrix blank
- Preliminary study:
- No significant responses were observed in any matrix blank solution at the retention time of the test item during analysis.
pH 4 at 50.0 ± 0.5 ºC: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 7 at 50.0 ± 0.5 ºC: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 9 at 50.0 ± 0.5 ºC: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C. - Test performance:
- The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 10 to 150 mg/L for each of the three analytical matrices used during the study. The results were satisfactory, with first order correlation coefficients (r) of 0.9998 being obtained for all three plots.
- Transformation products:
- not measured
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Conclusions:
- The hydrolysis of the test item, FRET 15-0735, was assessed according to OECD Test Guideline 111.
The estimated half-life of the test item at 25 °C is shown in the following table:
pH Estimated Half-life at 25 °C
4 >1 year
7 >1 year
9 >1 year - Executive summary:
Assessment of the hydrolytic stability of FRET 15-0735was carried out using a procedure designed to be compatible with Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The results are as follows:
pH
Estimated Half-life at 25 °C
4
>1 year
7
>1 year
9
>1 year
Reference
Preliminary Test
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 102 mg/L |
9.1348 x 106 |
Standard 102 mg/L |
9.1677 x 106 |
Initial Sample A, pH 4 |
9.0222 x 106 |
Initial Sample B, pH 4 |
9.0746 x 106 |
Standard 102 mg/L |
9.1752 x 106 |
Standard 102 mg/L |
9.2929 x 106 |
Initial Sample A, pH 7 |
9.1242 x 106 |
Initial Sample B, pH 7 |
9.1206 x 106 |
Standard 102 mg/L |
9.1911 x 106 |
Standard 102 mg/L |
9.2513 x 106 |
Initial Sample A, pH 9 |
9.0256 x 106 |
Initial Sample B, pH 9 |
9.0171 x 106 |
Standard 101 mg/L |
8.9849 x 106 |
Standard 100 mg/L |
8.9757 x 106 |
24 Hour Sample A, pH 4 |
9.0225 x 106 |
24 Hour Sample B, pH 4 |
9.0208 x 106 |
Standard 101 mg/L |
9.0898 x 106 |
Standard 100 mg/L |
9.0924 x 106 |
24 Hour Sample A, pH 7 |
9.1995 x 106 |
24 Hour Sample B, pH 7 |
9.1594 x 106 |
Standard 101 mg/L |
9.0191 x 106 |
Standard 100 mg/L |
9.0122 x 106 |
24 Hour Sample A, pH 9 |
9.0843 x 106 |
24 Hour Sample B, pH 9 |
9.0317 x 106 |
Standard 101 mg/L |
9.0175 x 106 |
Standard 100 mg/L |
9.0592 x 106 |
120 Hour Sample A, pH 4 |
8.9478 x 106 |
120 Hour Sample B, pH 4 |
9.1025 x 106 |
Solution |
Mean Peak Area |
Standard 101 mg/L |
9.1470 x 106 |
Standard 100 mg/L |
9.1502 x 106 |
120 Hour Sample A, pH 7 |
9.1354 x 106 |
120 Hour Sample B, pH 7 |
9.1006 x 106 |
Standard 101 mg/L |
9.0798 x 106 |
Standard 100 mg/L |
9.0518 x 106 |
120 Hour Sample A, pH 9 |
9.0420 x 106 |
120 Hour Sample B, pH 9 |
9.0586 x 106 |
pH 4 at 50.0 ± 0.5 ºC
Time (Hours) |
Concentration (g/L) |
% of mean initial concentration |
||
A |
B |
A |
B |
|
0 |
0.402 |
0.404 |
- |
- |
24 |
0.404 |
0.404 |
100 |
100 |
120 |
0.399 |
0.406 |
99.0 |
101 |
pH 7 at 50.0 ± 0.5 ºC
Time (Hours) |
Concentration (g/L) |
% of mean initial concentration |
||
A |
B |
A |
B |
|
0 |
0.403 |
0.402 |
- |
- |
24 |
0.407 |
0.405 |
101 |
101 |
120 |
0.402 |
0.401 |
99.9 |
99.6 |
pH 9 at 50.0 ± 0.5 ºC
Time (Hours) |
Concentration (g/L) |
% of mean initial concentration |
||
A |
B |
A |
B |
|
0 |
0.399 |
0.398 |
- |
- |
24 |
0.405 |
0.403 |
102 |
101 |
120 |
0.402 |
0.402 |
101 |
101 |
Description of key information
Assessment of the hydrolytic stability of FRET 15-0735was carried out using a procedure designed to be compatible with Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The results are as follows:
pH |
Estimated Half-life at 25 °C |
4 |
>1 year |
7 |
>1 year |
9 |
>1 year |
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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