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EC number: 826-544-6 | CAS number: 29118-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Title:
- Caesar hybrid model for bacterial reverse mutation (Ames test) version 2.1.13
- Year:
- 2 010
- Bibliographic source:
- Ferrari T, Gini G (2010) An open source multistep model to predict mutagenicity from statistical analysis and relevant structural alerts. Chemistry Central Journal , 4(Suppl 1):S2
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Ferrari T, Gini G (2010) An open source multistep model to predict mutagenicity from statistical analysis and relevant structural alerts. Chemistry Central Journal , 4(Suppl 1):S2. http://www.journal.chemistrycentral.com/content/4/S1/S2
The software is and is freely available through the portal of the CAESAR project.
Test material
- Reference substance name:
- (1Z)-1,3,3,3-tetrafluoroprop-1-ene
- EC Number:
- 826-544-6
- Cas Number:
- 29118-25-0
- Molecular formula:
- C3H2F4
- IUPAC Name:
- (1Z)-1,3,3,3-tetrafluoroprop-1-ene
Constituent 1
- Specific details on test material used for the study:
- C(=C\F)\C(F)(F)F
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimurium; strains not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- True negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
Applicant's summary and conclusion
- Conclusions:
- Mutagenicity (Ames test) model (CAESAR) version 2.1.13 predicts the substance is NON-MUTAGENIC.
- Executive summary:
The prediction of Mutagenicity (Ames test) model (CAESAR;version 2.1.13) on the target compound may be considered adequate. The main reason for the low ADI value is that the target compounds has a fragment defined by the SMILES: FC=C that is an uncommon fragment not present in the compounds of the training set of the model.
Despite the Applicability Domain tool within VEGA identifies some issues to be verified, using a weight of evidence approach combining several VEGA models and read-across, it allows to support a non mutagenic assessment for the target compound. Indeed, there is agreement between the prediction and all similar compounds containing Fluorine atoms, which are experimentally non mutagenic.
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