Registration Dossier
Registration Dossier
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EC number: 825-571-0 | CAS number: 60428-79-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- January 2014 (REG (EC) No. 440/2008 amended by REG (EU) No 260/2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- <= 0.1 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 8.2 - 8.3
- Details on results:
- The content of test item analyzed in the water sample was 0.00028 mg/L after one centrifugation step after which already no undissolved test item was visible. The content of test item analyzed in the water sample was 0.000055 mg/L after two consecutive centrifugation steps. The decrease in the concentration is probably caused by adsorbance of the test item between centrifugation steps.
The results for the samples taken at a flow rate set to 12 and 24 mL/h are given in "Adeka Corporation_Water_Solubility" (see attachment) for both the test item containing column and the blank column. The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates.
The coefficient of variation (CV) (n = 10) was ≤ 30% at both flow rates, which indicates an equilibrated test system at both flow rates. The maximum difference (MD) on the mean values of the samples at both flow rates was also ≤ 30%. However, in the samples from the blank column similar concentrations were detected. Correcting for the signals observed in the eluate from the blank column results in a water solubility of ≤ 0.1 μg/L.
The limit of detection (LOD) was 0.010 μg/L taking a dilution factor of 10 into account. - Conclusions:
- The test material is insoluble in water (≤ 0.1 μg/L).
Reference
Description of key information
water solubility ≤ 0.1 μg/L at 20 °C, pH 8 (EU A.6, OECD 105, OPPTS 830.7840)
Key value for chemical safety assessment
Additional information
Water Solubility ≤ 0.1 μg/L at the temperature of 20°C
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