Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vitro and in vivo studies
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Important considerations for the read-across were:
Sodium Olivoyl Glutamate (the target chemical) has similar physico-chemical properties as the others members:
- "Aliphatic acid category" (the source chemicals);
- "Amino acid alkyl amides category" (the source chemicals);
- Sodium oleoyl glutamate (the source chemicals);
Key points are that the members share:
- the same structural features
- similar metabolic pathways
- common levels and mode of human health related effects
- function.
Data source
Reference
- Reference Type:
- publication
- Title:
- OECD SIDS ALIPHATIC ACIDS CATEGORY
- Author:
- SIDS Initial Assessment Report
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Data available is referred to aliphatic acids category.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- not applicable
- Molecular formula:
- not applicable
- IUPAC Name:
- not applicable
1
- Specific details on test material used for the study:
- not specified
Test animals / tissue source
- Species:
- other: not specified
- Strain:
- not specified
- Remarks:
- not specified
- Details on test animals or tissues and environmental conditions:
- not specified
Test system
- Vehicle:
- not specified
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- not specified
- Duration of post- treatment incubation (in vitro):
- not specified
- Number of animals or in vitro replicates:
- not specified
- Details on study design:
- not specified
Results and discussion
In vitro
Results
- Irritation parameter:
- other: See conclusion
- Run / experiment:
- See conclusion
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: See conclusion
- Other effects / acceptance of results:
- See conclusion
In vivo
Results
- Irritation parameter:
- other: See conclusion
- Basis:
- other: See conclusion
- Time point:
- other: See conclusion
- Reversibility:
- other: See conclusion
- Remarks on result:
- other: See conclusion
- Irritant / corrosive response data:
- See conclusion
- Other effects:
- See conclusion
Any other information on results incl. tables
See conclusion
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No ocular irritation was observed in in vitro studies of acetyl tyrosine (up to 1.25%), disodium capryloyl glutamate (up to 2%), and sodium lauroyl glutamate (up to 5%). Severe irritation was observed with sodium cocoyl glutamate at 5% using the hen’s egg test chorioallantoic membrane (HET-CAM) method, but it was not irritating in another study with an unknown concentration. Slight irritation was observed with sodium lauroyl silk amino acids at 0.5% using the HETCAM method. Lauroyl arginine in a mixture at 10% was not irritating to rabbit eyes. No adverse effects were observed during in-use studies of eye-area products containing acetyl hydroxyproline (up to 2%) and acetyl tyrosine (up to 2%) in human participants.
- Executive summary:
Slight irritation was observed with sodium lauroyl silk amino acids at 0.5% using the HETCAM method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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