Registration Dossier
Registration Dossier
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EC number: 947-842-3 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21d) >= 3.96 mg/L a.i. for Daphnia magna (OECD 211)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 3.96 mg/L
Additional information
No long-term test with the test item fatty acid chloride, C12, reaction product with sodium glutamate and sodium hydroxide is available. No long-term test on invertebrates is required for Annex VIII. However, since invertebrates are the most sensitive species to the test item, this inclusion appears useful for evaluation and risk assessment. Therefore, the data of the anaolgue substance Sodium N-cocoyl glycinate were used.
The Lowest Observed Effect Concentration (LOEC) and the No Observed Effect Concentration (NOEC) for the reproductive output were determined directly from reduction of the reproductive output. EC10- and EC50- values for the reproductive output and the adult mortality could not be estimated because effects > 10 % were not observed.
As the concentrations in the old media (48 h) were below LOQ, the endpoints were assessed based on the nominal test item concentrations corrected with a factor of 2. Endpoint assessment based on mean measured concentrations is not possible, because the toxicity cannot be attributed to any single compound of the test item Hostapon SG containing different C-chains of the N-Cocoyl glycine sodium salt. Therefore, it was concluded that an evaluation on half of the nominal concentrations sufficiently describes a worst case scenario. Additionally the endpoints are given based on half of nominal concentrations of the active ingredient (a.i.) taking its content of 19.8 % into account.
NOECReproduction : 20 mg/L, corresponding to 3.96 mg a.i./L
LOECReproduction : > 20 mg/L, corresponding to > 3.96 mg a.i./L
NOECAdult Mortality : 20 mg/L, corresponding to 3.96 mg a.i./L
LOECAdult Mortality : > 20 mg/L, corresponding to > 3.96 mg a.i./L
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