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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data taken from IUCLID4 report with no information on methods or GLP status.

Data source

Reference
Reference Type:
review article or handbook
Title:
Characteristics of the General Toxic, Gonadatropic, and Mutagenic Effects of 1,3-chlorobromopropane
Author:
Eytingon, A.I.
Year:
1971
Bibliographic source:
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv, No. 12, p. 93-100

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline mentioned in data source.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-bromo-3-chloropropane
EC Number:
203-697-1
EC Name:
1-bromo-3-chloropropane
Cas Number:
109-70-6
Molecular formula:
C3H6BrCl
IUPAC Name:
1-bromo-3-chloropropane

Test animals

Species:
rat

Administration / exposure

Route of administration:
other: oral and inhalation
Duration of treatment / exposure:
28 days
Doses / concentrations
Remarks:
Doses / Concentrations:
0,045 & 0,0054 mg/liter
No. of animals per sex per dose:
6 animals per group

Examinations

Observations and examinations performed and frequency:
Various effects were seen from the high concentration : increased summation threshold index, decreased ability to eliminate sulfobromophthalein from the blood, and increased liver weight coefficients.
Sacrifice and pathology:
Histologically, liver changes included moderate albuminoid and fatty degeneration of the parenchyma and focal proliferation of the interstitial tissue cells. Few effects were seen as a result of the lower concentration ; histological effects were mild.
Other examinations:
After a one-month recovery period, the residual pathological processes were hardly noticeable, and were of a proliferative nature. Anaphase analysis of bone marrow cells showed higher number of chromosome aberrations in animals exposed to 0,45 mg/liter than in the control animals. Changes in germinal epithelium and a tendency towards reduction in testicular weight coefficient and spermatozoa motility time were noted.

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
There were no deaths in animals by the 24th day when animals had received 9 x LD50. During the next 4 days, animals tolerated daily doses nearly as high as the LD50.
Mortality:
mortality observed, treatment-related
Description (incidence):
There were no deaths in animals by the 24th day when animals had received 9 x LD50. During the next 4 days, animals tolerated daily doses nearly as high as the LD50.
Haematological findings:
effects observed, treatment-related
Description (incidence and severity):
decreased ability to eliminate sulfobromophthalein from the blood
Organ weight findings including organ / body weight ratios:
effects observed, treatment-related
Description (incidence and severity):
increased liver weight coefficients
Gross pathological findings:
effects observed, treatment-related
Description (incidence and severity):
increased summation threshold index
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Description (incidence and severity):
liver changes included moderate albuminoid and fatty degeneration of the parenchyma
Histopathological findings: neoplastic:
effects observed, treatment-related
Description (incidence and severity):
focal proliferation of the interstitial tissue cells.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The observations made on bone marrow cells reavealed chromosome aberrations in animals exposed to 0,45 mg/liter of the test substance : this tends to confirm a mutagenic potential of 1-bromo-3-chloropropane (see abstract in chapter 7.6).