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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: testicular function
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data taken from IUCLID4 report with no information on methods or GLP status.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline mentioned in data source.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-bromo-3-chloropropane
EC Number:
203-697-1
EC Name:
1-bromo-3-chloropropane
Cas Number:
109-70-6
Molecular formula:
C3H6BrCl
IUPAC Name:
1-bromo-3-chloropropane

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male
Details on test animals or test system and environmental conditions:
Sexually mature mice approximately 3 months of age

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Duration of treatment / exposure:
Exposure period: 5 consecutive days
Duration of test: six weeks
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
300, 600, 1200 mg/kg/day
Basis:

No. of animals per sex per dose:
4 males per dose
Control animals:
yes, concurrent vehicle
Details on study design:
After dosing, 1/6 of each group (4 treated and seven control rats) were sacrificed at the one week post treatment date. This process was repeated over the next five weeks.

Examinations

Postmortem examinations (parental animals):
At sacrifice, a smear of the contents of the cauda epididymidis was examined for spermatozoa and testes weighed before fixing and histological exam.

Results and discussion

Results: P0 (first parental generation)

General toxicity (P0)

Clinical signs:
no effects observed
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
no effects observed
Other effects:
effects observed, treatment-related
Description (incidence and severity):
Test substance intake: Twenty of the 24 mice in the 1200 mg/kg dose group died by the fifth dose.

Reproductive function / performance (P0)

Reproductive function: sperm measures:
no effects observed
Reproductive performance:
no effects observed

Details on results (P0)

No effects attributable to treatment were observed in mice given 600 mg/kg bodyweight or less in the areas of clinical signs of toxicity, bodyweight, spermatogenesis or testicular morphology.

Effect levels (P0)

Dose descriptor:
NOAEL
Effect level:
600 mg/kg bw/day
Based on:
test mat.
Sex:
male

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
According to the results of this test (testicular effects on mouse), 1-bromo-3-chloropropane has not to be considered as toxic to reproduction.