Registration Dossier
Registration Dossier
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EC number: 207-355-2 | CAS number: 464-49-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Bornan-2-one
- EC Number:
- 200-945-0
- EC Name:
- Bornan-2-one
- Cas Number:
- 76-22-2
- Molecular formula:
- C10H16O
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
- Test material form:
- solid: crystalline
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1g
- Duration of treatment / exposure:
- 1min
- Observation period (in vivo):
- 7d
- Number of animals or in vitro replicates:
- 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- other: 4 animals
- Time point:
- other: 4h,24h, 48h, 72h, 4d, 7d
- Score:
- 1
- Max. score:
- 1
- Irritation parameter:
- iris score
- Basis:
- other: 4 animals
- Time point:
- other: 4h,24h, 48h, 72h, 4d, 7d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 4h,24h, 48h, 72h, 4d, 7d
- Score:
- 0.667
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 4h,24h, 48h, 72h, 4d, 7d
- Score:
- 0.667
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 4h,24h, 48h, 72h, 4d, 7d
- Score:
- 0.333
- Max. score:
- 1
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- other: 4h,24h, 48h, 72h, 4d, 7d
- Score:
- 0.333
- Max. score:
- 1
- Irritation parameter:
- other: secretion
- Basis:
- other: 4 animals
- Time point:
- other: 4h,24h, 48h, 72h, 4d, 7d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 1h, 24h, 48h, 72h, 4d, 7d
- Score:
- 0.167
- Max. score:
- 1
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 1h, 24h, 48h, 72h, 4d, 7d
- Score:
- 0.333
- Max. score:
- 1
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 1h, 24h, 48h, 72h, 4d, 7d
- Score:
- 0.333
- Max. score:
- 1
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- other: 1h, 24h, 48h, 72h, 4d, 7d
- Score:
- 0.333
- Max. score:
- 1
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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