Registration Dossier
Registration Dossier
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EC number: 207-355-2 | CAS number: 464-49-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- no
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- this study report was performed in 2003
Test material
- Reference substance name:
- Bornan-2-one
- EC Number:
- 200-945-0
- EC Name:
- Bornan-2-one
- Cas Number:
- 76-22-2
- Molecular formula:
- C10H16O
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
- Test material form:
- solid: crystalline
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- vegetable oil
- Concentration / amount:
- 1g/mL
Challengeopen allclose all
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- vegetable oil
- Concentration / amount:
- 1g/mL
- No. of animals per dose:
- 15
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0.2ml
- No. with + reactions:
- 0
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 0.2ml. No with. + reactions: 0.0. Total no. in groups: 15.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.2mL
- No. with + reactions:
- 0
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.2mL. No with. + reactions: 0.0. Total no. in groups: 15.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- 1% DNCB 0.2mL
- No. with + reactions:
- 13
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: positive control. Dose level: 1% DNCB 0.2mL. No with. + reactions: 13.0. Total no. in groups: 15.0.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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