Registration Dossier
Registration Dossier
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EC number: 423-040-4 | CAS number: 125700-67-6 TBTU
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other: (robust) study summaries provided by ECHA
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 2-(1-H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
- EC Number:
- 423-040-4
- EC Name:
- 2-(1-H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
- Cas Number:
- 125700-67-6
- Molecular formula:
- C11H16N5O.BF4
- IUPAC Name:
- [(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylidene]dimethylazanium; tetrafluoroboranuide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HSD
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: 1% w/v aqueous methylcellulose
- No. of animals per sex per dose:
- Preliminary sighting study: 2 (female)
Main study: 10 (male)
Main study: 10 (female)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- other: fixed dose further
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No. with evident toxicity: 5; No. of deaths: 0; No. of animals used: 5
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: Signs of toxicity: Signs of toxicity included piloerection, abnormal body carriage, abnormal gait and increased salivation, seen among all rats at both doses. In addition, lethargy, decreased respiratory rate, partially closed eyelids, pallor of the extre
- Gross pathology:
- Effects on organs:
Amongst decedents changes to the majority of major organs
and tissues were observed. No treatment-related macroscopic
findings were observed in the surviving animals. - Other findings:
- All males dosed at 2000 mg/kg died during the study, all
deaths occured between 4 and 48 hours of dosing
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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