Registration Dossier
Registration Dossier
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EC number: 229-802-0 | CAS number: 6740-85-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11.09.2003 - 01.12.2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-chlorophenyl cyclopentyl ketone
- EC Number:
- 229-802-0
- EC Name:
- 2-chlorophenyl cyclopentyl ketone
- Cas Number:
- 6740-85-8
- Molecular formula:
- C12H13ClO
- IUPAC Name:
- 2-chlorophenyl cyclopentyl ketone
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study reports): JNJ-54582034-AAA (T003642)
- Physical state: liquid
- Appearance: yellow liquid
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: ambient temperature
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The analytical verification of the test item concentrations was carried out after 0 and 48 hours.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: Strauss clone 5.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20.2 - 20.5°C (mean: 20.4°C)
- pH:
- 7.7-8.4
- Dissolved oxygen:
- 8.1-8.7 mg/l
- Nominal and measured concentrations:
- nominal: 1.2, 2.3, 3.4, 6.3, 11.5, 18.9, 33.3 mg/L
initially measured (t=0h): 1.2, 2.1, 3.1,5.7,10.6,17.6, 30.5 mg/L
measured test concentrations after 48 h did not deviate by more than 20% (exception: 1.2 mg/ L) from the freshly prepared test solutions
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- The EC50-values were calculated by probit analysis according to CavalliSforza (1972).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48h EC50 value for immobilisation for the test item is 5.8 mg/L.
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