Registration Dossier
Registration Dossier
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EC number: 204-807-0 | CAS number: 126-83-0
Endpoint summary
Administrative data
Description of key information
In Vitro Skin Sensitisation: Negative; OECD Guideline 442D (ARE-Nrf2 Luciferase Test Method); Reliability=K1
In Chemico Skin Sensitisation: Negative; OECD Guideline 442C (Direct Peptide Reactivity Assay (DPRA)); Reliability=K1
WOE - Weight of evidence documentation for Non-Classification for skin sensitization of 1-Propanesulfonic acid, 3-chloro-2-hydroxy-, monosodium salt (NaCHPS)
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Base on the combined weight of evidence
1) 2 negative skin sensitization in-vitro results
2) 2 out of 3 Integrated Testing Strategy (ITS) data set adequate domain for substance
3) OECD toolbox predicting only SN2 protein binding alerts,
4) Danish QSAR database indicating likely negative for allergic dermatitis in humans or guinea pigs.
The substance is not classified for skin sensitization according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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