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EC number: 220-618-6 | CAS number: 2835-95-2
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Percent change in the concentration of 5-Amino-o-cresol in buffer solutions at pH 4, 7 and 9 was less than 10% after 5 days at 50 ± 0.5°C. Therefore, it was found to be hydrolytically stable under the test conditions at pH 4, 7 and 9.
Key value for chemical safety assessment
Additional information
The hydrolysis of 5-Amino-o-cresol was determined following OECD Guideline 111 (Hydrolysis as a function of pH) and the GLP.
The hydrolysis of the test substance was determined in 3 buffer solutions (pH 4, 7 and 9) at 50 ± 0.5°C.The analytical procedure, SMV (PC) 3200148-02V, for determining the content of 5 - Amino-o-cresol in aqueous buffer solutions was also developed in this study.
Test solutions were prepared by dissolving appropriate amount of test substance in the buffer solutions (pH 4, 7 or 9) and diluting to the mark with that same buffer.Three vials were filled for each test solution and one for buffer solution (which served as control). All the vials were incubated for 5 days at 50 ± 0.5°C. The samples from each test and buffer solutions were analyzed at the beginning (Day 0) and after 5 days incubation period by using High Performance Liquid Chromatography with UV detection (HPLC-UV). All the test solutions were diluted 0.25 mL to 10 mL with diluent prior to analysis.
The analytical procedure was successfully validated for the quantification of 5 -Amino-o-cresol in aqueous solutions at pH 4, 7 and 9.
Based on the results, percent change in the concentration of 5 -Amino-o-cresol in buffer solutions at pH 4, 7 and 9 was less than 10% after 5 days at 50 ± 0.5°C. Therefore, it was found to be hydrolytically stable under the test conditions at pH 4, 7 and 9.
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