Registration Dossier
Registration Dossier
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EC number: 248-742-6 | CAS number: 27939-60-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of the substance to microorganisms was investigated in an activated sludge respiration inhibition study according to OECD TG 209 and in compliance with GLP criteria (IFF, 2017). In this study non-adapted activated sludge from a predominantly domestic sewage was exposed to nominal test substance loading rates of 0 (control), 46, 100, 220, 460 and 1000 mg/L for 3 hours. The effects on microorganisms were determined by measuring total respiration rates and comparing these to an unexposed control. No statistically significant inhibition of the respiration rate of the sludge was recorded at or below a loading rate of 100 mg/L. At higher loading rates, the inhibitory effect of Vertoliff increased with increasing loading rate, ranging from 18% inhibition at 220 mg/L to 79% at 1000 mg/L. Based on these findings, the 3-h ELR50 and ELR10 values were determined at 436 and 138 mg/L, respectively.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 436 mg/L
- EC10 or NOEC for microorganisms:
- 138 mg/L
Additional information
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