Registration Dossier
Registration Dossier
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EC number: 266-411-4 | CAS number: 66576-71-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Klimisch 1
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
IMB is of low toxicity in acute toxicity in an acute oral study. A reproductive toxicity screening study is available for the closely related analogue, EMB, which showed no evidence of effects on fertility (NOAEL 1000mg/kg bw/day). Therefore, additional animal studies to investigate potential reproduction toxicity are not scientifically justified.
Effects on developmental toxicity
Description of key information
No effects seen.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Reason / purpose for cross-reference:
- read-across source
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Klimisch 1
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Description of key information
Ne effects observed
Additional information
IMB is of low toxicity in acute toxicity in an acute oral study. A reproductive toxicity screening study is available for the closely related analogue, EMB, which showed no evidence of effects on fertility (NOAEL 1000mg/kg bw/day). Therefore, additional animal studies to investigate potential reproduction toxicity are not scientifically justified.
Justification for classification or non-classification
A 54 day repeat dose study with reproductive / developmental toxicity screening with the read-across substance EMB showed no toxicity. IMB shows no toxicity in any other studies. Consequently this substance will not be classified as toxic to reproduction.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
