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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Remarks:
- the tested substance is the acid part of the compound
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Safepharm Standard Test Method Number 513.01
- Principles of method if other than guideline:
- A group of three fasted males and three fasted females were treated with the starting dose (2000 mg/kg bw). As the females dosed with 2000 mg/kg bw died, a further three fasted males and three fasted females were treated with the dose level 300 mg/kg bw. The test material was administered orally as a solution in distilled water. The animals were observed 1/2, 1, 2, and 4 hours after dosing and then once daily for up to 14 days. Bodyweights were recorded on Day 0 (day of dosing) and on Days 7 and 14 or at death. At the end of the observation period the surviving animals were killed by cervical dislocation and all animals were subject to gross necropsy.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: compact
- Details on test material:
- - Name of test material (as cited in study report):Benzene sulfonic acid, C10-16-alkyl derivatives (68584-22-5)
This substance (dodecylbenzene sulfonic acids (CAS# 27176-87-0)) is from the category of LAB Sulfonic Acids, which includes the following three chemicals:
Benzene sulfonic acid, C10-16 alkyl derivatives (CAS# 68584-22-5),
Benzene sulfonic acid, dodecyl (CAS# 27176-87-0), and,
Benzene sulfonic acid, tridecyl (CAS# 25496-01-9).
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled
- Details on oral exposure:
- The test material was administered orally as a solution in distilled water. The animals were observed 1/2, 1, 2, and 4 hours after dosing and then once daily for up to 14 days.
- Doses:
- 300,2000
- No. of animals per sex per dose:
- 9
- Control animals:
- yes
- Details on study design:
- A group of three fasted males and three fasted females were treated with the starting dose (2000 mg/kg bw). As the females dosed with 2000 mg/kg bw died, a further three fasted males and three fasted females were treated with the dose level 300 mg/kg bw. The test material was administered orally as a solution in distilled water. The animals were observed 1/2, 1, 2, and 4 hours after dosing and then once daily for up to 14 days. Bodyweights were recorded on Day 0 (day of dosing) and on Days 7 and 14 or at death. At the end of the observation period the surviving animals were killed by cervical dislocation and all animals were subject to gross necropsy
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 775 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 value is geometric mean between 300 and 2000 mg/kg bw.
- Mortality:
- Three females were found dead one day after dosing at the 2000 mg/kg bw dose level. There were no deaths at the 300 mg/kg bw dose level.
- Clinical signs:
- No clinical signs of toxicity were noted in animals treated with 300 mg/kg bw.
- Body weight:
- The surviving animals showed expected gains in body weight over the study period.
- Gross pathology:
- Abnormalities noted at necropsy of animals that died duringthe study were abnormally red lungs, dark liver, and dark kidneys.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The acute oral LD50 in male/female rats is 775 mg/kg bw. LD50 value is geometric mean between 300 and 2000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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