Alkylbenzenesulphonic acid compound with alkanolamine

Hydrolysis

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Administrative data

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

the tested substance is the acid component of the compound

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes (incl. QA statement)

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

other: liquid

Details on test material:

Dodecylbenzenesulfonic acid , purity = 96.87%LG Household & Health care, Lot. No. 080108C105

Radiolabelling:

not specified

Study design

Analytical monitoring:

yes

Buffers:

Buffer solution were sterilized through the 0.2 μm cellulose acetate filter. The composition of buffer solutions was as follows:- pH 4.0 : 0.1 N NaOH 0.4 mL + 0.1 M Potassium biphthalate 50 mL Dissolved in deionized water and made up to 100 mL- pH 7.0 : 0.1 N NaOH 29.63ml + 0.1 M Monopotassium 50 mL Dissolved in deionized water and made up to 100 mL- pH 9.0 : 0.1 N NaOH 21.3ml + 0.1 Boric acid in 0.1 M KCl 50 mL Dissolved in deionized water and made up to 100 mL

Details on test conditions:

All glassware used in the hydrosis test were sterilized and buffer solutions were taken to avoid oxygen and all of the Hydrosis test was carried out under dark condition.

Results and discussion

Preliminary study:

Triplicate sterile aqueous buffer solutions (250 mL) of different pH values of 4.0, 7.0 and 9.0 were treated with test substance to make 50 ppm.The test was performed at 50 +/- 5 deg C for 5 days. Individual replicate samples were sampled at application (0 day) and 5 days.And samples were quantified by HPLC.

Transformation products:

not measured

Dissipation DT50 of parent compound

Dissipation DT50 of parent compound 1

pH:

4

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, the acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.

Dissipation DT50 of parent compound 2

pH:

7

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, the acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.

Dissipation DT50 of parent compound 3

pH:

9

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, the acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.

Details on results:

The preliminary test results showed that the percent hydrolysis at pH 4.0, 7.0 and 9.0 were negative values after 5 days respectively. These results were less than 10% of hydrolysis and then test substance was considered hydrolytically stable and no additional testing was requiredby the OECD Guidelines.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Since the chemical is degradable less than 10% after 5 days in this test condition, it is presumably stable in water. (Hydrolytically stable)

Executive summary:

This study was performed following “OECD Guidelines for Testing of Chemicals No. 111: Hydrolysis as function of pH. The preliminary test was performed at 50 ±5°C and pH 4, 7 and pH 9. The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, the test substance was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines