Registration Dossier
Registration Dossier
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EC number: 205-771-9 | CAS number: 150-78-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 apr 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study well described and following the guideline, but not GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: UV/VIS spectroscopy
- Type:
- log Pow
- Partition coefficient:
- 2.08
- Temp.:
- 23 °C
- Remarks on result:
- other: no data on pH are provided
- Details on results:
- See tables below:
- Conclusions:
- With a log Pow of 2.08, Paradimethoxybenzene has a low potential of bioaccumulation.
- Executive summary:
The partition coefficient (log Pow) of the test substance Paradimethoxybenzene was determined according to the OECD guideline 107.
In this study (Clariant, 2008), the shake-flask method was used.
The test substance concentrations in each phase was determined by UV/VIS spectroscopy.
The partition coefficient of Paradimethoxybenzene was determined to be 2.08.
Reference
Results in detail:
Determ n° |
Stock solution (ml) |
Water (ml) |
Substance conc. In n-octanol phase (mg/L) |
Test substance conc. In water phase (mg/L) |
Log Pow |
A1 A2 |
10 10 |
20 20 |
740.4 740.4 |
6.2 6.1 |
2.08 2.08 |
B1 B2 |
20 20 |
20 20 |
742.5 743.1 |
6.2 6.2 |
2.08 2.08 |
C1 C2 |
40 40 |
20 20 |
747.5 746.5 |
6.4 6.4 |
2.07 2.06 |
Mean |
/ |
/ |
/ |
/ |
2.08 |
Recovery rate of test substance:
Determ n° |
Test substance in stock solution (mg) |
Test substance in n-octanol phase (mg) |
Test substance in water phase (mg) |
Sum (mg) |
Recovery rate (%) |
A1 A2 |
7.5 7.5 |
7.4 7.4 |
0.12 0.12 |
7.53 7.53 |
100 100 |
B1 B2 |
15 15 |
14.85 14.86 |
0.12 0.12 |
14.97 14.99 |
100 100 |
C1 C2 |
30 30 |
29.9 29.86 |
0.13 0.13 |
30.03 29.99 |
100 100 |
Description of key information
One study (Clariant, 2008) has been chosen as key study. The shake-flask method was used, according to the OECD guideline 107.
The test substance concentrations in each phase was determined by UV/VIS spectroscopy.
The partition coefficient of Paradimethoxybenzene was determined to be 2.08.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.08
- at the temperature of:
- 20 °C
Additional information
Other literature values are in the same range.
Paradimethoxybenzene has a low potential for bioaccumulation.
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