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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No enough details. Documentation is insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
Author:
Hodge HC, Sterner JH, Maynard EA, Thomas J.
Year:
1949
Bibliographic source:
J. Ind. Hyg. Toxicol. 31, 79-92.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dimethoxybenzene
EC Number:
205-771-9
EC Name:
1,4-dimethoxybenzene
Cas Number:
150-78-7
Molecular formula:
C8H10O2
IUPAC Name:
1,4-dimethoxybenzene
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS:
- Species: rat
- Strain: no data
- Sex: no data
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: Average weight of animals:
- group tested at 1000 mg: 175 g
- group tested at 1250 mg: 172 g
- group tested at 1500 mg: 176 g
- group tested at 1750 mg: 130 g.
- Fasting period before study: no data
- Housing: no data
- Food consumption: no data
- Water consumption: no data
- Acclimation period: no data

Environmental conditions: no data

In-life dates: no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
- Maximum dose volume applied: 1750 mg
- Dosage preparation (if unusual): no data
- Rationale for the selection of the starting dose: no data
Doses:
1000; 1250; 1500; 1750 mg corresponding to 5714 mg/kg, 7267 mg/kg, 8522 mg/kg and 13461 mg/kg.
No. of animals per sex per dose:
for doses of 1000, 1250 and 1500 mg, 10 animals per dose.
For dose of 1750 mg, only one animal.
Sex unspecified.
Control animals:
no
Details on study design:
- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- examinations performed: other: no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 500 mg/kg bw
Mortality:
2/10 died at dose of 1000 mg (5714 mg/kg), whereas, 5/10 died at dose of 1500 mg (8522 mg/kg). One rat treated at dose of 1750 mg/kg, died.
Clinical signs:
other: no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

The doses were not indicated in mg/kg bw but only in mg. The LD50 was calculated in accordance with weight of animals.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
According to EU and UN GHS criterias, the substance is not classified for acute oral toxicity.
Executive summary:

In a oral acute study, rats were exposed to 5714 mg/kg, 7267 mg/kg, 8522  mg/kg and 13461 mg/kg of the test substance. The LD50 is 8500 mg/kg. Based on this value, the substance is not classified for acute oral toxicity.