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EC number: 218-817-8 | CAS number: 2243-62-1
Endpoint summary
Administrative data
Description of key information
In order to establish the maximum tolerated concentrations of the test substance for administration to dosed animals in a chronic study, a subchronic toxicity study was conducted with Fischer-344 -rats of both sexes.
The concentrations used were: 0.03; 0.1; 0.3; 1.0 and 3.0 %(ca. 20, 67, 200, 667 or 2000 mg/kg/d) . The dosed dietary preparations were administered for 8 weeks.
Deaths were recorded for all groups of rats receiving concentrations of 0.3 % or more (no Nr. of animals given).
Mean body weight depression was approximately 19 and 9 %, respectively, in males and females dosed with 0.1 % of test substance. No effect level based on this study. Only bw. And mortality examined.
The dose chosen as highest concentration of test substance in the rat chronic bioassay was 0.1 %.
Additionally a subchronic toxicity study was conducted with B6C3F1 mice of both sexes.
The concentrations used were: 0,03; 0,1; 0,3; 1,0 and 3,0 %(ca. 43, 143, 429, 1429 or 4286 mg/kg/d) . The dosed dietary preparations were administered for 8 weeks.
Deaths were recorded for all groups of mice receiving concentrations of 0,3 % or more (no Nr. of animals given).
Mean body weight depression was approximately 22 and 3 %, respectively, in males and females dosed with 0,3 % of test substance.
Males receiving 0,1 % experienced mean body weight depression of approximately 3 %.
The highest concentration of test substance in the mouse chronic bioassay was 0,2 % (NCI 1978).
25 female Wistar-rats received 1,5 -naphthylenediamine by gavage (dose: 0; 2; 10; 50 mg/kg bw.) daily from day 6 to day 15 of gestation.
From 10 mg/kg bw./day the food consumption and weight gain were influenced.
In the 50 mg/kg dose group sporadic heightened urine excretion was observed and additionally in one animal an increased water consumption detected.
No meaningfull pathological-anatomical findings and no mortalities were observed.
From 10 mg/kg bw/day a marginal diminuated weight of fetuses was identified.
The NOAEL f...
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
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