Registration Dossier
Registration Dossier
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EC number: 218-817-8 | CAS number: 2243-62-1
Endpoint summary
Administrative data
Description of key information
1,5.naphthylenediamine (Alphamin) is of moderate acute oral toxicity:
In an acute oral study female Wistar rats were treated with one single dose of the test substance Alphamin (500; 550; 600; 800; 1000; 1500 mg/kg
bw.).
10 rats per dose group were treated and observed for 14 days.
Following symptoms were observed: narcosis, rough hair, diminuated general condition, weight loss after the first week of experiment.
No macroscopical pathological findings were observed in the authopsy.
The LD50 was 634 mg/kg bw. (Loeser 1981 a).
Male rats, were treated with one single dose of the test substance Alphamin (1500; 2000; 2500; 2800; 3100 mg/kg bw.).
10 rats per dose group and observed for 14 days.
Following symptoms were observed: narcosis, rough hair, diminuated general condition, weight loss.
No macroscopical pathological findings were observed in the authopsy.
The LD50 was 2100 mg/kg bw. (Loeser 1981 b)
In an acute inhalation toxicity study according to OECD guideline 403, 5 male and 5 female Wistar rats (170 -200g) per group were treated with the
test substance for 4 hours.
The observation period was 14 days.
Symptoms of toxicity observed were: reduced motility, decelerated breathing, ruffled hair (occurred in the second half of the first week of the
observation period); 2 females died after 4 days; macroscopical findings in female rats: hydrothorax, reddened renal pelvis, dark and enlarged
spleen, pale liver with marked lobules, reddened gastrointestinal tract.
The LC50 for male rats was > 5.27 mg/l.
The LC50 for female rats was ca. 5.27 mg/l.
The NOEL was 2.01 mg/l (Pauluhn 1988).
In an acute dermal toxicity study according to guideline 84/449/EWG, 5 male and 5 female Wistar-rats (median weight: 253, 197 g resp.) were
treated with 2000 mg/kg of the test substance (in Cremophor EL).
The application time was 24h and the observation period 14 days.
No systemic or local symptoms of toxicity were observed. The LD 50 was > 2000 mg/kg bw. (Bomhard 1988).
Key value for chemical safety assessment
Additional information
Acute toxicity: oral
Effect level: LD50 female rats: 634 mg/kg bw.
LD50 male rats: 2100 mg/kg bw.
Acute toxicity: dermal
Effect level: LD50: >2000 mg/kg bw.
Acute toxicity: inhalation
Effect level: LC50: >5,27 mg/l.
NOAEL: 2,01 mg/l.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
