Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-525-9 | CAS number: 131860-97-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Summary report signed by the study director of the original GLP study, plus one internal reviewer. The toxicological information contained in the report is derived from studies which fulfil the requirements of good laboratory practice. The report format does not give all informations required by the guideline: Some experimental details, body weights, and individual data are not provided. Doses are spaced by a factor of 3, instead of 2 as required in the guideline.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- Not explicitly stated in report
- Deviations:
- not specified
- GLP compliance:
- yes
- Remarks:
- Confirmed by study director
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
- IUPAC Name:
- Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
- Reference substance name:
- 603-525-9
- EC Number:
- 603-525-9
- Cas Number:
- 131860-97-4
- Molecular formula:
- C15H13ClN2O4
- IUPAC Name:
- 603-525-9
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 1%, 3%, 10% w/v
- No. of animals per dose:
- no data
- Positive control substance(s):
- not specified
- Statistics:
- no data
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 10.78
- Test group / Remarks:
- 10% w/v
- Parameter:
- SI
- Value:
- 2.87
- Test group / Remarks:
- 3% w/v
- Parameter:
- SI
- Value:
- 0.81
- Test group / Remarks:
- 1% w/v
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Vehicle only (DMF): 63 CPM / lymph node 1% w/v: 51 CPM / lymph node 3% w/v: 181 CPM / lymph node 10% w/v: 679 CPM / lymph node
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Conclusions:
- The available study (CTL, Robinson) was conducted under GLP. While the full study report is not available, the results are sufficiently detailed and unambiguous as to be suitable for classification and labeling.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
