(Methyl (E)-2-[(6-chloro-1,3 pyrimidine-4-oxy)phenyl]-3-methoxyacrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1992-03-12 to 1992-04-02

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Summary report signed by the study director of the original GLP study, plus one internal reviewer. The toxicological information contained in the report is derived from studies which fulfil the requirements of good laboratory practice. The report format does not give all informations required by the guideline: Some experimental details and individual data are not provided. The study was conducted according to a method similar to OECD Guidelines with some deviations: exposure was only for 1 hour; maximum concentration tested was <5mg/L.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

not stated in report

Deviations:

yes

Remarks:

Exposure time 1 hour, maximum concentration tested 1.89 mg/liter, no limit test

GLP compliance:

yes

Remarks:

Confirmed by study director

Test type:

other: acute method, 1-hr exposure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-

IUPAC Name:

Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-

Constituent 2

Reference substance name:

603-525-9

EC Number:

603-525-9

Cas Number:

131860-97-4

Molecular formula:

C15H13ClN2O4

IUPAC Name:

603-525-9

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

not specified

Vehicle:

not specified

Analytical verification of test atmosphere concentrations:

yes

Remarks:

Determination of atmospheric concentration and mass median aerodynamic diameter, no methods specified

Duration of exposure:

1 h

Remarks on duration:

no rationale given

Concentrations:

1.89 mg/liter, +/- 0.11 mg/liter (SD)
mass median aerodynamic diameter 4.86 micrometer, geometric standard deviation 2.33

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

Observation period 14 days
Post-mortem examination

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

1.89 mg/L air

Based on:

test mat.

Exp. duration:

1 h

Mortality:

None

Clinical signs:

other: No adverse clinical effects Slight irritant effect in two males immediately after exposure General recovery by day 2, but slight piloerection in some animals throughout the 14-day observation period

Body weight:

No data

Gross pathology:

No treatment-related changes

Applicant's summary and conclusion

Interpretation of results:

other: Not conclusive

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

While the full study report is not available, the results are sufficiently detailed and unambiguous. The 1-hour inhalation LC50 is >1890 mg/m3.
For aerosols, which are normally not secondarily exhaled, an approximate extrapolation to the usual 4-hour exposure can be based on Haber's rule (Miller FJ, Schlosser PM & Janszen DB, Toxicology, 2000, 149, 22-34). This calculation results in a four- hour inhalation LC50 >470 mg/m3.