Registration Dossier
Registration Dossier
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EC number: 267-041-6 | CAS number: 67763-18-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
According to Regulation (EC) No. 1907/2006, Annex IX, Column 2, 9.1.6, the testing of the long-term to fish is not required.
Key value for chemical safety assessment
Additional information
The substance Diisooctadecyl malate (CAS 67763-18-2) is readily biodegradable and poorly soluble in water (6.5-13.5 µg/L at 20 °C). Due to these characteristics, extensive elimination of the substance in conventional STPs can be expected. Therefore, only low concentrations, if any, are likely to be released into the water phase. Exposure of aquatic organisms like fish to the substance is thus expected to be low. Furthermore, read across data on short-term toxicity available for all three trophic levels (fish, aquatic invertebrates and algae) indicate a low potential for aquatic toxicity. Chronic effects of the substance are not expected based on the expected environmental fate and on the data on acute toxicity of the substance.
As there was no sign that fish is the most sensitive species in the short-term tests, one can expect that a long-term test with fish will not generate different results than the available studies with aquatic organisms. Hence due to animal welfare reasons and to avoid unnecessary vertebrate tests, no further long-term test with fish is proposed for Diisooctadecyl malate (CAS 67763-18-2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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