Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 219-210-0 | CAS number: 2387-03-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 2387-03-3
- Author:
- Danish (Q)SAR Database
- Year:
- 2 016
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.
Materials and methods
- Principles of method if other than guideline:
- Data is predicted using the Danish (Q)SAR Database
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- EC Number:
- 219-210-0
- EC Name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- Cas Number:
- 2387-03-3
- Molecular formula:
- C22H16N2O2
- IUPAC Name:
- 1,1'-(hydrazine-1,2-diylidenedimethylylidene)di(2-naphthol)
- Reference substance name:
- Yellow 101
- IUPAC Name:
- Yellow 101
- Test material form:
- not specified
- Details on test material:
- Name of test material (as cited in study report): 2-Hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone- Molecular formula (if other than submission substance): C22H16N2O2- Molecular weight (if other than submission substance): 340.38 g/mol- Smiles notation (if other than submission substance): Oc1c(c2c(cccc2)cc1)\C=N\N=C\c1c2c(cccc2)ccc1O- InChl (if other than submission substance): 1S/C22H16N2O2/c25-21-11-9-15-5-1-3-7-17(15)19(21)13-23-24-14-20-18-8-4-2-6-16(18)10-12-22(20)26/h1-14,25-26H/b23-13+,24-14+- Structural formula attached as image file (if other than submission substance): No data available- Substance type: Organic- Physical state: No data available- Analytical purity: No data available- Impurities (identity and concentrations): No data available- Composition of test material, percentage of components: No data available- Isomers composition: No data available- Purity test date: No data available- Lot/batch No.: No data available- Expiration date of the lot/batch: No data available- Radiochemical purity (if radiolabelling): No data available- Specific activity (if radiolabelling): No data available- Locations of the label (if radiolabelling): No data available- Expiration date of radiochemical substance (if radiolabelling): No data available- Stability under test conditions: No data available- Storage condition of test material: No data available- Other: No data available
Constituent 1
Constituent 2
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Table: Table showing the domain applicability estimated by four different models i.e, CASE Ultra, Leadscope and SciQSAR & the average domain applicability was given by the fourth model i.e, Battery model.
Battery | CASE Ultra | Leadscope | SciQSAR | |
Sex-Linked Recessive Lethal (SLRL) Test in Drosophila m.
| NEG_IN | NEG_OUT | NEG_IN | NEG_IN |
Where,
IN = inside applicability domain
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negativeThe test compound induces no gene mutation in Drosophila melanogaster, estimated by four different models i.e, Battery, CASE Ultra, Leadscope and SciQSAR used within Danish QSAR database.Thus, the test was found to be negative.
- Executive summary:
The mutagenic potency of test substance Yellow 101 was estimated by four different models i.e, Battery, CASE Ultra, Leadscope and SciQSAR used within Danish QSAR database.
Sex Linked Recessive Lethal (SLRL) Test was performed using Drosophila melanogaster as the test animal.
Based on the four different models i.e, Battery, CASE Ultra, Leadscope and SciQSAR used within Danish QSAR database, it was found that the test compound Yellow 101 induces no gene mutation in Drosophila melanogaster.Thus, the test was found to be negative.
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