Registration Dossier
Registration Dossier
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EC number: 241-893-9 | CAS number: 17976-32-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No studies are availabe for 3-methoxyestra-2,5(10)-dien-17-one (CAS number17976-32-8). Results 'read across' from studies with 3-methoxyestra-2,5(10)-dien-17ß-ol (CAS number1091-93-6) based on structural similarities as justified in the internal communication by R. Länge to J. Polomski (June 9, 2000).
A combined study on acute dermal toxicity and on local tolerance was conducted with the analogue. The study design and reporting deviates from the current OECD TG 404, however, the study was considered sufficient for assessment of skin irritation/corrosion. In this study a single dermal administration of the test substance for 24 hours to male and female rats at a dose of 2000 mg/kg (approx. 218 mg/male and 209 mg/female applied as a paste) was tolerated without any local irritations. The mean values of findings relevant for classification (reddening, scab formation and swelling of the skin) at the time-points 24, 48 and 72 hours after the end of administration were 0 according to the system recommended in Directive 67/548/EEC.
In a local tolerance test on the rabbit eye according to OECD TG 405 a single application of the analogue into the conjunctival sac provoked slight to moderate irritation which lasted for 2 - 3 days and gradually faded away on days 4 - 5 after application. The mean values of findings relevant for classification at the time-points 24, 48 and 72 hours after application were 0 for the parameters cornea and iris, 0.1 for conjunctival swelling and 0.9 for conjunctival reddening. According to EU classification criteria the test substance need not be labelled as an eye irritant.
Justification for classification or non-classification
Based on the study results of the analogue a classification according to Directive 67/548/EEC or Regulation (EC) No. 1272/2008 (CLP) is not warranted.
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