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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Principles of method if other than guideline:
Laser diffraction method - The test was conducted according to the guidance of the apparatus used. A short description is given below:
The dry test substance is dispersed and passes a laser in form of an aerosol. In dependence on the particle size the laser is diffracted. The resulting so called “Fraunhofer” diffraction spectrum is bundled using a converging lens in a multi-element photo detector. In dependence of the particle size distribution a radial symmetric intensity distribution is generated. The measured intensity is analysed by a computer and converted into a particle size distribution.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
ca. 46.68 µm
Key result
Percentile:
D50
Mean:
73.96 µm
Remarks on result:
other: SD not determined
No.:
#1
Size:
32.81 µm
Distribution:
10 %
No.:
#2
Size:
73.96 µm
Distribution:
50 %
No.:
#3
Size:
288.64 µm
Distribution:
95 %
No.:
#4
Size:
364.3 µm
Distribution:
98 %
No.:
#5
Size:
510 µm
Distribution:
100 %
Conclusions:
The median value of particle size of Creatinine is 73.96 µm.
Executive summary:

The granulometric properties of Creatinine were analysed with the laser diffraction method according to guideline ISO 13320-1. The particle size distribution was determined using the particle size analyser HELOS KF (H0119) from Sympatec with a Sympatec RODOS dry dispersing unit. The test material was dried via dispersing and run in form of an aerosol fluent through a laser beam. The median value of particle size is 73.96 µm.

Description of key information

The median value of particle size of Creatinine is 73.96 µm.

Additional information

The granulometric properties of Creatinine were analysed with the laser diffraction method according to guideline ISO 13320 -1. The particle size distribution was determined using the particle size analyser HELOS KF (H0119) from Sympatec with a Sympatec RODOS dry dispersing unit. The test material was dried via dispersing and run in form of an aerosol fluent through a laser beam. The median value of particle size is 73.96 µm.