Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-466-7 | CAS number: 60-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.09.2002 - 11.10.2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- no data
- Vehicle:
- no
- Details on test solutions:
- A stock solution of the test substance with a concentration of 1000 mg/L was prepared in reconstituted water. Further dilutions of the test substance were made in reconstituted water (according to Guideline ISO 6341).
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUSS
- Source: Landesamt für Wasserwirtschaft München
- Method of breeding: Subparts of the culture are cultivated in 2 L beakers in approx. 1,7 L hatching medium. Every 3-4 days the cultures are transfered into new medium and the young animals are separated from the older ones by sieving. The daphnids are fed every day with an aliquot of a culture of single cell green algae.
- Feeding during test: none
ACCLIMATION
- Acclimation period: not necessary because animals were hatched in the laboratory (under the same conditions as in the test) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no data
- Hardness:
- no data
- Test temperature:
- Temperature was stable during the test period (20 °C)
- pH:
- 7.4 - 7.9
- Dissolved oxygen:
- 6.8 - 8.4
- Salinity:
- no data
- Nominal and measured concentrations:
- Preliminary test: 0, 1, 2, 10, 100, 33, 500 mg/L
Main Test: 0, 250, 333, 500, 1000 mg/L - Details on test conditions:
- See "any other infomraion on material and methods"
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- see "any other information on results"
- Results with reference substance (positive control):
- To check the correct performance of the test procedure and the sensitivity of the test animals a reference test was periodically performed with potassium dichromate. The last reference test was performed in June 2002. The EC50 value (EC50 24 h; 1,4 mg/L) was within the limit of 0.6 - 1,7 mg/L indicated in ISO 6341.
- Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results show that at a test substance concentration of 1000 mg/L no daphnids were immobilized. Therefore the EC50 of Creatinine is > 1000 mg/L.
- Executive summary:
The acute toxicity of Creatinine on Daphnia magna was determined in a 48 hours static test following the pattern of EEC Commission Directive 92/69, C.2 "Acute Toxicity for Daphnia magna". Animals of Daphnia magna, not more than 24 hours old, were exposed to different concentrations of the test substance in reconstituted water according to ISO 6341. A negative control group was exposed to reconstituted water only. In the test 20 daphnids, divided into 4 replicates (5 daphnia each) were used for each concentration and for the control group. The results show that at a test substance concentration of 1000 mg/L no daphnids were immobilized. Therefore the EC50 of Creatinine is > 1000 mg/L.
Reference
Description of key information
The results show that at a test substance concentration of 1000 mg/L no daphnids were immobilized.
Therefore the EC50 of Creatinine is > 1000 mg/L.
Key value for chemical safety assessment
Additional information
The acute toxicity of Creatinine on Daphnia magna was determined in a 48 hours static test following the pattern of EEC Commission Directive 92/69, C.2 "Acute Toxicity for Daphnia magna". Animals of Daphnia magna, not more than 24 hours old, were exposed to different concentrations of the test substance in reconstituted water according to ISO 6341. A negative control group was exposed to reconstituted water only. In the test 20 daphnids, divided into 4 replicates (5 daphnia each) were used for each concentration and for the control group. The results show that at a test substance concentration of 1000 mg/L no daphnids were immobilized. Therefore the EC50 of Creatinine is > 1000 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.