Registration Dossier
Registration Dossier
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EC number: 939-201-1 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (98h) = 62.4 mg/L (nominal, based on active matter) for Leuciscus idus (OECD 203, read across)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 62.4 mg/L
Additional information
No studies investigating the short-term toxicity of Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid to freshwater fish are available. Thus, available data for the source substances l-Glutamic acid, N-coco acyl derivs., monosodium salts (CAS No. 68187-32-6) and stearic acid (CAS No. 57-11-4) were used in a read across approach. The read across approach is considered valid since l-Glutamic acid, N-coco acyl derivs., monosodium salts is structurally very similar to the main component and stearic acid is identical to the second, quantitatively relevant, component of the multiconstituent substance.
l-Glutamic acid, N-coco acyl derivs., monosodium salts is structurally identical to the main component L-Glutamic acid, N-(1-oxooctadecyl)-, monosodium salt only differing in the length of the carbon side chain. Whereas the length of the carbon side chain of l-Glutamic acid, N-coco acyl derivs., monosodium salts may vary between C6 to 18, the carbon side chain of L-Glutamic acid, N-(1-oxooctadecyl)-, monosodium salt is C18 only. As the relevant physico-chemical properties (log Kow < 1, water solubility = high) are similar which assumes identical environmental behavior and as molecules with shorter carbon side chains are expected to be up taken more easily into organisms, the source substance can be considered as worst case scenario for assessing the ecotoxicity of the main component of Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid.
The read across key study was performed according to GLP and OECD guideline 203 using Leuciscus idus as test organism (Hoechst, 1990). A 32 % solution of the UVCB substance in water was tested. Nominal concentrations between 48 and 64 mg/L (based on active matter) were tested over a period of 96 h. The 96h-LC50 is determined to be 62.4 mg/L. Supporting studies showed no toxicity of stearic acid to fish in the highest tested concentrations resulting in a 48h-LC50 > 10,000 mg/L (Henkel, 2001) and a 96h-LC50 > 12 mg/L (Leach & Thakore, 1977), respectively.
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