Registration Dossier
Registration Dossier
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EC number: 234-829-6 | CAS number: 12035-72-2
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Adequacy of study:
- supporting study
- Rationale for reliability incl. deficiencies:
- other: A summary of health surveillance data is provided in the Executive Summary.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Endpoint Summary:
Health surveillance data were reported in four separate studies, only two of which were considered robust (i.e., scored as K1/K2).
A study reported on the prevalence of small opacities in radiographs collected from workers at a sinter plant with significant nickel oxide exposures; no appreciable disease in the study population based on both round and irregular opacities (Muir et al.,1993).
Torjussen and Andersen (1979) reported that nickel concentrations in urine, blood and nasal mucosa samples significantly correlated with the length of nickel exposure. These authors also reported that levels in workers were significantly higher than a related control group, and that levels were different between current and retired workers. Thus, these data demonstrate correlations between levels of nickel and occupational exposures.
Three K3/K4 studies conducted by the same laboratory reported on the incidence of chromosomal aberrations and sister chromatic exchanges in the peripheral lymphocytes of nickel refinery workers. Increases in chromosomal aberrations, but not sister chromatid exchanges, were noted in the small sample of workers.
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