Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-433-1 | CAS number: 8002-26-4
Endpoint summary
Administrative data
Description of key information
Crude Tall Oil was found to be not irritant to rabbit skin and eyes in reliable studies conducted according to the appropriate OECD test guidelines and in compliance with GLP (Wolf, 2005).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
The only available study for skin irritation (reliability 1) was an in vivo test carried out in accordance with OECD Test Guideline 404 (Wolf, 2005). No skin reactions were observed up to and including the 72 hour observation. CTO was therefore judged to be non-irritant to rabbit skin.
Eye irritation:
The only available study for eye irritation (reliability 1) was an in vivo test carried out in accordance with OECD Test Guideline 405 (Wolf, 2005). Minor effects were observed at the 1 hour observation, but at no other time point. CTO was therefore judged to be non-irritant to rabbit eyes.
Skin corrosion:
The only available study specifically targeted at skin corrosion was an in vitro test carried out in accordance with OECD Test Guideline 430 (Weiss-Fuchs, 2005). The mean TER of Crude Tall Oil treated skins was 21.2 kΩ, which is above the threshold of 5 kΩ for classification.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on in vitro and in vivo data, CTO does not meet the criteria for classification as irritant or corrosive according to the criteria of EU Directive 67/548/EEC or Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
