Registration Dossier
Registration Dossier
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EC number: 231-448-7 | CAS number: 7558-79-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary only available in English. A full English summary is not considered necessary as the data does not conflict with any of the more up to date studies conducted on disodium phosphate.
Data source
Reference
- Reference Type:
- publication
- Title:
- Minimal eventually lethal dose intravenous Na2HPO4
- Author:
- Osser S
- Year:
- 1 933
- Bibliographic source:
- Arch Ital Sci Faracol. 2(5): 478-494
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium hydrogenorthophosphate
- EC Number:
- 231-448-7
- EC Name:
- Disodium hydrogenorthophosphate
- Cas Number:
- 7558-79-4
- Molecular formula:
- H3O4P.2Na
- IUPAC Name:
- disodium hydrogen phosphate
- Details on test material:
- - Name of test material (as cited in study report): acid sodium phosphate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
The acid sodium phosphate when intravenously injected in high doses in the rabbits, causes the death of the animal under characteristic tetanus-like contractions. When smaller doses are used the animal dies under a constant depressive syndrome. The minimal lethal dose is equivalent to 1075 g/kg.
Applicant's summary and conclusion
- Conclusions:
- The acid sodium phosphate when intravenously injected in high doses in the rabbits, causes the death of the animal under characteristic tetanus-like contractions. When smaller doses are used the animal dies under a constant depressive syndrome. The minimal lethal dose is equivalent to 1075 g/kg.
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