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Registration Dossier
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EC number: 231-448-7 | CAS number: 7558-79-4
Toxicity to birds
Administrative data
- Endpoint:
- long-term toxicity to birds: reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract ony, original reference in a foreign language.
Data source
Reference
- Reference Type:
- publication
- Title:
- Über die wirkung von polyphosphaten auf hühnerembuonen.
- Author:
- Von Bärbel Karb
- Year:
- 1 971
- Bibliographic source:
- Zeitschrift fuer Tierphysiologie, Tierernaehrung und Futtermittelkunde 27 (5) 237 - 51.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Deviations:
- not specified
- Principles of method if other than guideline:
- Sodium metaphosphate, pentasodium triphosphate and disodium hydrogenphsphate-2-hydrate were injected in different concentrations into the air chamber of eggs and incubated for 72 h.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP.
Test material
- Reference substance name:
- Disodium hydrogenorthophosphate
- EC Number:
- 231-448-7
- EC Name:
- Disodium hydrogenorthophosphate
- Cas Number:
- 7558-79-4
- Molecular formula:
- H3O4P.2Na
- IUPAC Name:
- disodium hydrogen phosphate
- Details on test material:
- - Name of test material: Sodium metaphosphate, pentasodium triphosphate, disodium hydrogenphosphate-2-hydrate.
Constituent 1
- Dose method:
- other: Injection into the egg air sac.
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Chicken
Study design
- Limit test:
- no
- Remarks:
- Single injection.
- No. of animals per sex per dose and/or stage:
- Not applicable, administration was to eggs.
- Control animals:
- not specified
Results and discussion
- Repellency factors (if applicable):
- No data
Any other information on results incl. tables
No influence could be seen by injection of an increasing dose of 0.7 to 10 mg and 30 mg pentasodium triphosphate and sodium metaphosphate after 72 h. The injection of 15 mg pentasodium triphosphate per egg after 24 h was shown to be ineffective. The same dose of sodium metaphosphate per egg after 24 h was shown to be ineffective. The same dose of sodium metaphosphate showed a lethal effect. A noxious effect was observed after injection of 5 mg/egg. The lethal dose was abruptly obtained by injection of 10 - 15 mg/egg. Embryos of 2nd and 3rd brooding day showed characteristic misshapes of the brain, heart and primordium and the somites. Histological investigations resulted in anomalies of the brain primordium, the degeneration of the neurocanal, an enlargement of the erythrocyteless embryonical vessels and a swelling of mesenchym cells and their nuclei.
The injection of 15 mg disodium hydrogen phosphate-2-hydrate 24 h after brooding had no noxious effect.
Later injections of sodium metaphosphate had not toxic effect, thus the embryo might be able to detoxicate sodium metaphosphate between the 2nd and 3rd brooding day.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- No influence could be seen by injection of an increasing dose of 0.7 to 10 mg and 30 mg pentasodium triphosphate and sodium metaphosphate after 72 h. The injection of 15 mg pentasodium triphosphate per egg after 24 h was shown to be ineffective. The same dose of sodium metaphosphate per egg after 24 h was shown to be ineffective. The same dose of sodium metaphosphate showed a lethal effect. A noxious effect was observed after injection of 5 mg/egg. The lethal dose was abruptly obtained by injection of 10 - 15 mg/egg. Embryos of 2nd and 3rd brooding day showed characteristic misshapes of the brain, heart and primordium and the somites. Histological investigations resulted in anomalies of the brain primordium, the degeneration of the neurocanal, an enlargement of the erythrocyteless embryonical vessels and a swelling of mesenchym cells and their nuclei.
The injection of 15 mg disodium hydrogen phosphate-2-hydrate 24 h after brooding had no noxious effect.
Later injections of sodium metaphosphate had not toxic effect, thus the embryo might be able to detoxicate sodium metaphosphate between the 2nd adn 3rd brooding day.
Study is not considered to be of relevance for REACH registration and therefore results cannot be used in a meaningful way and should be disregarded.
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