Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-680-9 | CAS number: 109-55-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Extrapolating local lymph node assay EC3 values to estimate relative sensitizing potency
- Author:
- Ryan CA, Kern PS, Dearman RJ, Kimber I and Basketter DA
- Year:
- 2 007
- Bibliographic source:
- Cutaneous and Ocular Toxicology, 26, 135-145, 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 3-aminopropyldimethylamine
- EC Number:
- 203-680-9
- EC Name:
- 3-aminopropyldimethylamine
- Cas Number:
- 109-55-7
- Molecular formula:
- C5H14N2
- IUPAC Name:
- N,N-dimethylpropane-1,3-diamine
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 - 12 weeks
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0.5; 1.0; 2.5; 5.0; 10.0%
- No. of animals per dose:
- a minimum of 4 animals
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 13.9
- Test group / Remarks:
- 10% test substance
- Parameter:
- SI
- Value:
- 3.5
- Test group / Remarks:
- 5% test substance
- Parameter:
- SI
- Value:
- 1.1
- Test group / Remarks:
- 1.0% test substance
- Parameter:
- SI
- Value:
- 1.3
- Test group / Remarks:
- 0,5% test substance
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Vehicle: 463 Test material: 0.5%: 597 1.0%: 486 2.5%: 1626 5.0%: 3223 10.0%: 6417
Any other information on results incl. tables
EC3: 2.2% (EC3 value derived by linear interpolation);
EC3: 2.3% (EC3 values derived by log-linear extrapolation).
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
