Registration Dossier
Registration Dossier
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EC number: 203-680-9 | CAS number: 109-55-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
DMAPA is with high probability is not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 122 mg/L
Additional information
The key study, originally performed by Hoechst (1980) uses Leuciscus idus as test species in an acute test according to German Industrial Standard DIN 38412 -15 (similar to OECD 203). The exposure duration was 96 h. The stability of the test substance 3-aminopropyldimethylamine (CAS 109-55-7) in the test medium has not been analytically verified, but is considered to be stable due to the high water solubility (WS = 1E+06 mg/L), the low Henry´s law constant (uncharged: 6.71E-04 Pa*m3/mol) and the low adsorption potential (log Kow and log Koc < 3) of the substance. The study was performed using not pH-adjusted test solutions. The test substance causes a pH-shift to more alkaline conditions with increasing test substance concentrations, resulting in a maximum pH value of 10.6 in the highest test concentration (500 mg/L). The acceptable pH range for fish given in the OECD TG 203 (pH 6.0 to 8.5) was therefore not kept in all test concentrations. The 96-h LC50 was determined to be 122 mg/L (nominal). Due to the high pH value in the highest test concentration, an influence of the pH value on the toxicity of the substance towards fish cannot be excluded.
The experimental result is supported by an estimated LC50 of 1010 mg/L. The LC50 was predicted using the automated workflow for acute toxicity to fish of the OECD QSAR Toolbox v4.5. The substance is in the applicability domain of the model.
In conclusion, DMAPA is with high probability not harmful to fish.
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