Bis(2-dimethylaminoethyl)(methyl)amine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions - limited description of test animals - observation duration of 8 days only

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

(limited documentation, observation duration of only 8 days)

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-dimethylaminoethyl)(methyl)amine

EC Number:

221-201-1

EC Name:

Bis(2-dimethylaminoethyl)(methyl)amine

Cas Number:

3030-47-5

Molecular formula:

C9H23N3

IUPAC Name:

(2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl)dimethylamine

Details on test material:

- Name of test substance (as cited in study report): Pentamethyl-diaethylen-trieamin
- Analytical purity: no data
- Physical state: liquid
- Density: 0.829 g/cm³
- Substance number: XXIII/80

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Source: Gassner
- Mean weight at study initiation: 192.5 g (males); 181.5 g (females)

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 30%, 16%, 8% and 2% (v/v)

MAXIMUM DOSE VOLUME APPLIED: ca. 10.6 mL/kg bw

Doses:

3200, 1600, 800 and 200 µL/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 8 days
- Frequency of observations: daily
- Frequency of weighing: doumentation on day 0
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 330 mg/kg bw

Based on:

test mat.

95% CL:

> 663 - < 2 653

Remarks on result:

other: Corresponds to ca. 1600 µL/kg bw; Conversion based on a density of 0.829 mg/cm³.

Mortality:

- 3200 µL/kg bw: 10/10 animals died within 24 h after application.
- 1600 µL/kg bw: 4/10 animals died within 8 days after application (1 male within 8 days, 1 female within 24 h and 2 more females within the following 24 h after application)
- 800 and 200 µL/kg bw: 0/10 animals died

Clinical signs:

other: - 3200 µL/kg bw: increased respiration (immediately after application); abdominal position (few minutes after application); crouched position, irregular respiration and slight apathy (few hours after application); crouched position, increased respiration

Gross pathology:

- Animals that died: general hyperaemia, heart dilatation, hydrothorax, grey-brown liver, liquid content of intestine, edema of glandular stomach, dilated ecchymosis, injected stomach vessels, diarrhoeic content of intestine.
- Sacrificed animals: no abnormalities