Registration Dossier
Registration Dossier
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EC number: 271-756-9 | CAS number: 68607-24-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Epicutaneous patch test
Test material
- Reference substance name:
- Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides
- EC Number:
- 271-756-9
- EC Name:
- Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides
- Cas Number:
- 68607-24-9
- Molecular formula:
- The substance is a quarternary ammonium chloride derived from fatty alcohol. The general chemical structure is R-N(Me)3+ Cl-, whereas the alkylrest R is variable for the main components C20 and C22 but also shorter and longer C-Chains (in smaller amounts)
- IUPAC Name:
- N,N,N-trimethyl-C20-22-(even numbered)-alkyl-1-aminium chloride
Constituent 1
Method
- Type of population:
- general
- Subjects:
- Test type: Epicutaneous patch test with 1.0 % behentrimonium chloride in water
Subjects: Healthy male and female volunteers, age 17-80 years, nine of which with allergies, without visible skin lesions at the start of the study
Group size: 19 male and 31 female subjects - Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Details on exposure:
- 1.0 % behentrimonium chloride in water
The test substance was applied to the skin of the back using usual test chambers. The test site was covered occlusively by adhesive plaster for 24 hours. - Examinations:
- - Other: Skin reactions were evaluated 0 and 24 hours after removal of test patches.
Results and discussion
- Results of examinations:
- No signs of skin irritation were detected in any subject at 0 as well as at 24 hours after application.
Applicant's summary and conclusion
- Conclusions:
- 1.0 % behentrimonium chloride in water produced no skin irritation when applied under occlusion for 24 hours in a human epicutaneous patch test.
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