Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-949-9 | CAS number: 2580-78-1
Categories
- Category name:
- 7.4.1 - EC 219-949-9 & EC 274-397-6 - Reactive Blue 19 & Reactive Blue 69
Justifications and discussions
- Category definition:
- See section “1. HYPOTHESIS FOR THE CATEGORY APPROACH” of the attached report: “7.4.1 - EC 219-949-9 & EC 274-397-6 - Reactive Blue 19 & Reactive Blue 69 – Reasoning.pdf”.
- Category description:
- See section “3. CATEGORY APPROACH JUSTIFICATION” of the attached report: “7.4.1 - EC 219-949-9 & EC 274-397-6 - Reactive Blue 19 & Reactive Blue 69 – Reasoning”.
- Category rationale:
- The choice of the target and the potential source substances that compose the category was based on a clustering method described in “7.4.1 - EC 219-949-9 & EC 274-397-6 - Reactive Blue 19 & Reactive Blue 69 – ClusteringMethod.pdf”. This method allows to calculate the similarity of each potential source with the targets and the similarity among the targets. The comparison between two molecules is based on the Tanimoto Coefficient that compares the Daylight fingerprints (as calculated in Python by RDKit) of the two molecules.
In this case, among the pool of potential sources (the ones with a reliable value for the endpoint of interest) the sources Orasol Blau 761B (EC 414-110-5), Acid Blue 344 (EC 400-350-8) and Reactive Blue FC 60866 (EC 414-040-5) were selected based on their similarity with the targets [Similarity Indexes range from 0.753 to 0.862] and the quality of the available data.
Moreover, a table containing the comparison between the physicochemical properties of targets and sources is reported in section “4. DATA MATRIX” of the attached report: “7.4.1 - EC 219-949-9 & EC 274-397-6 - Reactive Blue 19 & Reactive Blue 69 – Reasoning.pdf”.
The target and the source substances can be considered in the applicability domain of the category due to their high structural similarity [Similarity Index ≥ 0.753] and their similar physicochemical properties [see section “4. DATA MATRIX” of the attached report: “7.4.1 - EC 219-949-9 & EC 274-397-6 - Reactive Blue 19 & Reactive Blue 69 – Reasoning.pdf”].
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
