Registration Dossier
Registration Dossier
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EC number: 210-817-6 | CAS number: 623-84-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- circa 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- 0.01 ml of test material was applied to the intact skin of 5 rabbits.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propane-1,2-diyl diacetate
- EC Number:
- 210-817-6
- EC Name:
- Propane-1,2-diyl diacetate
- Cas Number:
- 623-84-7
- Molecular formula:
- C7H12O4
- IUPAC Name:
- propane-1,2-diyl diacetate
- Details on test material:
- Groups of 5 rats received 8.0 or 16.0 ml/kg and observed for 14 days. A gross pathologic examination is conducted.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: No data. New Zealand albino rabbits used in other sections of the same report.
- Details on test animals or test system and environmental conditions:
- The nonfasted animals are maintained on appropriate Rockland diets and water ad lib except during period of manipulation or confinement.
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
- Details on study design:
- Chemical is applied in 0.01 ml amounts to clipped intact skin of 5 rabbit bellies undiluted
Results and discussion
In vivo
Results
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No injury from undiluted application observed.
- Other effects:
- No additional information available.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- No skin irritation was noted following application of 0.01 ml to the belly. Although the dose was a tenth of the dose typically used, no dermal irritation was noted in the dermal LD50 study where rabbits were dosed with 16 ml/kg.
- Executive summary:
The skin irritation potential of PGDA was examined. No skin irritation was noted following application of 0.01 ml to the belly. Although the dose was a tenth of the dose typically used, no dermal irritation was noted in the dermal LD50 study where rabbits were dosed with 16 ml/kg.
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