Registration Dossier
Registration Dossier
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EC number: 203-308-5 | CAS number: 105-55-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Embryotoxicity of industrial chemicals on the chicken embryo: Thiourea derivatives.
- Author:
- Korhonen A., Hemminki K, Vainio H.
- Year:
- 1 982
- Bibliographic source:
- Acta pharmacol. et toxicol., 1982; 51: 38-44.
- Reference Type:
- publication
- Title:
- Toxicity of rubber chemicals towards three-day chicken embryos
- Author:
- KORHONEN-A, HEMMINKI-K, VAINIO-H
- Year:
- 1 983
- Bibliographic source:
- SCAND-J-WORK-ENVIRON-HEALTH 9 115-119
Materials and methods
- Type of study / information:
- in vitro test, on chicken embryo
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-diethyl-2-thiourea
- EC Number:
- 203-308-5
- EC Name:
- 1,3-diethyl-2-thiourea
- Cas Number:
- 105-55-5
- Molecular formula:
- C5H12N2S
- IUPAC Name:
- 1,3-diethyl-2-thiourea
Constituent 1
Results and discussion
Any other information on results incl. tables
EMBRYOTOXIC EFFECTS:
- Test substance mainly caused early deaths and a dose-response was observed.
Rate of early deaths =
. 3 % of embryos at 1.0 µmol/egg,
. 77 % at 4.0 µmol/egg,
. 100 % at the highest doses (i.e. at 6.0 and 8.0 µmol/egg).
- No embryo that died late was observed as malformed.
- 3 to 7 % of survivors were malformed at the lowest doses (from 1.0 to 4.0 µmol/egg).
- 2 to 7 % of the late dead were not malformed at the lowest doses (from 1.0 to 3.0 µmol/egg).
CALCULATED PARAMETERS:
. ED50 = 3.1 µmol/egg
. LD 50 for total mortality = 3.3 µmol/egg
. LD50 for dead not malformed = 3.3 µmol/egg
. LD50 for early deaths = 3.4 µmol/egg
MAIN INDUCED MALFORMATIONS:
- small eye cup (17% of malformated survuivals)
- lack of lids and cornea or parts of them (50% of malformated survivals)
- open coelom (50% of malformated survivals)
- defects of back and neck (33% of malformated survivals).
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