Registration Dossier
Registration Dossier
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EC number: 245-846-3 | CAS number: 23727-15-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 28-09-2020
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- (-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Data source
Materials and methods
Test material
- Reference substance name:
- (S)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
- EC Number:
- 245-846-3
- EC Name:
- (S)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
- Cas Number:
- 23727-15-3
- Molecular formula:
- C10H16O
- IUPAC Name:
- 2-[(1S)-2,2,3-trimethylcyclopent-3-en-1-yl]acetaldehyde
- Details on test material:
- - Name of the test item (as cited in the study report): (-) CAMPHOLENIC ALDEHYDE
- IUPAC Name of the test item: (S)-2,2,3-trimethylcyclopenten-3-ene-1-acetaldehyde
- Substance type: monoconstituent
- Physical state: liquid
- Analytical purity: 87.1%
- Impurities (identity and concentrations): pinocamphone : 5.6%
- Purity test date: 2013-01-10
- Lot/batch No.: D60
- Expiration date of the lot/batch: January 2015
- Storage condition of test material: +2°C to +8°C, under nitrogen and protected from light
Constituent 1
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Remarks on result:
- positive indication of skin sensitisation
Any other information on results incl. tables
QSAR study result
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- DEREK Nexus evaluation showed alerts for skin sensitisation. Therefore, the test substance is considered as skin sensitiser according to EU and UN GHS criteria.
- Executive summary:
DEREK software ( Derek Nexus: 6.1.0, Nexus: 2.3.0, Lhasa Ltd.) was used to predict the mutagenicity of the test substance.
The query structure does match structural alerts or examples for skin sensitisation in Derek. All the evaluations for several animals are PLAUSIBLE.
DEREK Nexus evaluation showed alerts for skin sensitisation. Therefore, the test substance is considered as skin sensitiser and classified into category 1, H317 according to EU and UN GHS criteria.
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