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EC number: 245-846-3 | CAS number: 23727-15-3
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity for (+) CAMPHOLENIC ALDEHYDE was determined to be > 2000 mg/kg bw according to a study performed in agreement with OECD Guideline 401.
(-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- (-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: Just after the treatment, and during the first six hours following administration of the test substance, a slight piloerection was noticed in all animals with a decrease in motor activity and in muscle tone (staggering gait) appearing 1 hour after treatme
- Gross pathology:
- Gross necroscopy of animals 14 days after treatment did not show any visible organic or tissular lesions which may imply a possible systemic toxicity of the test substance.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the acute oral toxicity of the test substance was determined to be LD50 >2000 mg/kg bw.
- Executive summary:
In a GLP compliant acute oral toxicity study conducted in line with standardised guideline OECD 401, the acute oral toxicity of the test substance was determined. Under the conditions of the test, the LD50 of the test substance in rats was determined to be >2000 mg/kg bw and so the substance is considered to be unclassified for acute oral toxicity.
Reference
Table 1: Individual animal bodyweights
| Animal number | D1 | D4 | D8 | D15 | D15 -D1 |
| Male | |||||
9285 |
185.0 | 201.6 | 264.0 | 331.8 | 146.8 |
| 9286 | 172.2 | 193.3 | 251.8 | 311.0 | 138.8 |
| 9287 | 180.6 | 202.0 | 264.8 | 324.7 | 144.1 |
| 9288 | 203.8 | 207.9 | 262.9 | 332.3 | 128.5 |
| 9289 | 178.4 | 192.3 | 255.4 | 307.7 | 129.3 |
| Mean | 184.0 | 199.4 | 259.8 | 321.5 | 137.5 |
| SD | 12.0 | 6.5 | 5.8 | 11.6 | 8.4 |
| Female | |||||
| 9290 | 182.2 | 184.5 | 215.7 | 233.2 | 51.0 |
| 9291 | 187.6 | 199.5 | 238.3 | 264.8 | 77.2 |
| 9292 | 190.8 | 203.2 | 227.4 | 259.3 | 68.5 |
| 9293 | 180.8 | 189.4 | 235.9 | 258.6 | 77.8 |
| 9294 | 172.0 | 189.9 | 221.6 | 238.4 | 66.4 |
| Mean | 182.7 | 193.3 | 227.8 | 250.9 | 68.2 |
| SD | 7.2 | 7.8 | 9.5 | 14.1 | 10.9 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is GLP complaint and has Klimisch score of 1.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Substance is an intermediate and only available data need to be submitted.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral
The key study was performed in line with GLP and a standardised guideline at a single dose of 2000 mg/kg. No mortality occurred during the study and so the LD50 for the test substance was set as >2000 mg/kg bw. The study was selected as the key study on the basis that it was performed in line with GLP and a standardised guideline.
Justification for classification or non-classification
Oral
According to Regulation (EC) No 1272/2008, the studies available suggest that the test substance is considered to be unclassified for acute oral toxicity.
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