Registration Dossier
Registration Dossier
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EC number: 911-254-5 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Meets the requirements of GLP. There are no deviations from the recommended guideline.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Transformation products:
- not specified
- Remarks on result:
- not measured/tested
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Stable at pH 4, 7 and 9 at 25ºC
- Executive summary:
In a study of the abiotic hydrolysis of 6-tert-butyl-2,4-xylenol, according to the OECD guideline 111 and complying GLP, it was found that this substance is stable at pH 4, 7 and 9 at 25 ºC.
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Transformation products:
- not specified
- Key result
- Remarks on result:
- not measured/tested
- Conclusions:
- Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be stable at pH 4, 7 and 9, at 25ºC.
- Executive summary:
In a experimental study 6-tert-butyl-2,4-xylenol was found to be stable at pH 4, 7 and 9, at 25ºC. Based on these results, the read-across approach was applied and the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol was determined to be also stable at pH 4, 7 and 9, at 25ºC.
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
No scientifically justified due to lack of hydrolysable functional groups.
Referenceopen allclose all
Stable at pH 4, 7 and 9 at 25ºC.
Stable at pH 4, 7 and 9 at 25ºC.
Description of key information
Key study: Experimental result: read-across from results obtained in a test according to OECD Guideline 111. GLP study.
Stable at pH 4, 7 and 9, at 25ºC.
Data waiving:
The hydrolysis study is not scientifically justified due to lack of hydrolysable functional groups in the substance.
Key value for chemical safety assessment
Additional information
Key study: In a experimental study 6-tert-butyl-2,4-xylenol was found to be stable at pH 4, 7 and 9, at 25ºC. Based on these results, the read-across approach was applied and the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol was determined to be also stable at pH 4, 7 and 9, at 25ºC.
Data waiving:
The hydrolysis study is not scientifically justified due to lack of hydrolysable functional groups in the substance.
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