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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test done before GLP and Guidelines were established.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Hazardous Substances and Articles, Section 1500.41
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,7,9-Tetramethyldec-5-yne-4,7-diol, ethoxylated
EC Number:
500-022-5
EC Name:
2,4,7,9-Tetramethyldec-5-yne-4,7-diol, ethoxylated
Cas Number:
9014-85-1
Molecular formula:
variable
IUPAC Name:
2,4,7,9-Tetramethyl-5-decyne-4,7-diol, ethoxylated

Test animals

Species:
rabbit
Strain:
other: albino rabbits

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact / abraded
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
24 hours
Observation period:
72 hours
Number of animals:
six

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Remarks:
intact skin
Basis:
animal: 1-6
Time point:
24/48/72 h
Score:
0.5
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: no observation at 48 h
Irritation parameter:
erythema score
Remarks:
abraded skin
Basis:
animal: 1-6
Time point:
24/48/72 h
Score:
0.5
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: no observation at 48 h
Irritation parameter:
edema score
Remarks:
intact skin
Basis:
animal: 1-6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
other: no observation at 48 h
Irritation parameter:
edema score
Remarks:
abraded skin
Basis:
animal: 1-6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
other: no observation at 48 h

Any other information on results incl. tables

Rabbit Number
Erythema and Eschar Formation Reading (Hours) 1 2 3 4 5 6 Average
Intact Skin 24 1 1 1 1 1 1 1.00
Intact Skin 72 0 0 0 0 0 0 0.00
Abraded Skin 24 1 1 1 1 1 1 1.00
Abraded Skin 72 0 0 0 0 0 0 0.00
Subtotal 2.00
Edema Formation
Intact Skin 24 0 0 0 0 0 0 0.00
Intact Skin 72 0 0 0 0 0 0 0.00
Abraded Skin 24 0 0 0 0 0 0 0.00
Abraded Skin 72 0 0 0 0 0 0 0.00
Subtotal 0.00
Primary Irritation Score: 2.00 : 4 =0.50 Total 2.00

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
THE SUBJECT MATERIAL WOULD NOT BE CLASSIFIED AS A PRIMARY IRRITANT TO ALBINO RABBITS WITHIN THE DEFINITION OF THE ACT REFERENCE: SECTION 1500.3 AND REQUIRES NO CAUTIONARY LABELING WITH RESPECT TO THAT SECTION.
Executive summary:

THE SUBJECT MATERIAL WOULD NOT BE CLASSIFIED AS A PRIMARY IRRITANT TO ALBINO RABBITS WITHIN THE DEFINITION OF THE ACT REFERENCE: SECTION 1500.3 AND REQUIRES NO CAUTIONARY LABELING WITH RESPECT TO THAT SECTION.