Registration Dossier
Registration Dossier
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EC number: 203-528-1 | CAS number: 107-87-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-pentanone
- IUPAC Name:
- 2-pentanone
- Reference substance name:
- methyl n-propyl ketone
- IUPAC Name:
- methyl n-propyl ketone
- Reference substance name:
- Pentan-2-one
- EC Number:
- 203-528-1
- EC Name:
- Pentan-2-one
- Cas Number:
- 107-87-9
- Molecular formula:
- C5H10O
- IUPAC Name:
- pentan-2-one
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Basis:
- other:
- Remarks on result:
- other: Scoring was based on observation and not done with a numerical scale
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Methyl n-propyl ketone was considered to be a skin irritant.
- Executive summary:
Methyl n-propyl ketone was applied to the skin of Guinea Pigs. The test article was considered to be a slight skin irritant.
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