Pentan-2-one

Viscosity

Link to relevant study record(s)

Reference

Endpoint:

viscosity

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 2013

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Test Guideline 114 (Viscosity of Liquids)

Deviations:

no

GLP compliance:

no

Type of method:

capillary viscometer (static)

Temp.:

other: 25.0°C

Parameter:

dynamic viscosity (in mPa s)

Value:

0.607

*INFORMATION REQUIREMENTS-Two physical requirements are key to determination of aspiration hazard potential. Low viscosity and low surface area (<33mN/cm) determine the potential of a substance to constitute an aspiration hazard to the lung. Low viscosity leads to flow and low surface tension leads to spread through the respiratory tract. In addition, low solubility appears to be correlated with the ability of substances to penetrate the lungs.

 

METHOD

 

The kinematic viscosity at 25 ⁰C was determined using a capillary viscometer with Cannon-Ubbelodhe viscometer tube #50. Temperature control was provided by a thermostatically-controlled water bath. The dynamic viscosity was then calculated using density data at 25 ⁰C which were obtained using a Mettler DE40 oscillating tube densitometer.

 

PROCEDURE

 

The accuracy of the viscometer was validated by determining the dynamic viscosity of standard reference oil N1.0 from Cannon instruments at 25 ⁰C. Using the density data supplied with the standard, the dynamic viscosity was determined to be 1.2252 mPa-s, compared to the reference value of 1.179 mPa-s.

 

The viscometer sample reservoir was filled with the sample and the tube was immersed in the water bath with a set temperature of 25 ⁰C. The tube was allowed to equilibrate to the water bath temperature for 15 minutes. The sample was then drawn into the measurement chamber with vacuum, the vacuum released, and the sample was allowed to drain from the reservoir. The time required for the sample to drain from the upper mark to the lower mark of the viscometer tube was measured in seconds by a stopwatch. Using the drain time, the calibration constant for the viscometer tube, and the density of the liquid, the dynamic viscosity of the sample in cP (mPa-s) was calculated.

 

CALCULATIONS

 

The dynamic viscosity was calculated using the following equation:

 

Dymanic viscosity = t x C x Rho

 

Where

  t = drain time in seconds

  C = viscometer tube constant

  Rho = density at test temperature

 

For this test, t = 108.3 seconds

                      C = 0.006954 cSt/s

                 Rho = 0.8058 g/mL

 

RESULTS/CONCLUSION

 

The dynamic viscosity at 25 ⁰C was determined to be 0.6069 +/- 0.10 mPa-s.

Conclusions:

The dynamic viscosity at 25 ⁰C was determined to be 0.6069 +/- 0.10 mPa-s.

Executive summary:

The dynamic viscosity at 25 ⁰C was determined to be 0.6069 +/- 0.10 mPa-s.

Description of key information

The viscosity of the test substance was determined to be 0.6069 mPa/s, at a temp of 25C.

Key value for chemical safety assessment

Viscosity:

0.607 mPa · s (dynamic)

at the temperature of:

20 °C